• 1972 Kikuchi and Fujumoto
• prevalent in the East Asia
• exaggerated T-cell response
• probably the result of viral infection (EBV, HHV-6 etc)

• young women (F:M=4:1)
• unilateral cervical lymph nodes
• fever, sorethroat, skin rash etc
• leukopenia, raised ESR

• initial lymphoproliferative phase
• slowly evolving necrotic phase
• final resolving xanthomatous phase

• discreet areas of cortical necrosis
• abundant nuclear dusts
• lymphohistiocytic infiltrates, immunoblasts and large atypical cells
• absent neutrophil and plasma cells

• incomplete architectural effacement
• patent sinuses
• mottled appearance
• numerous histiocytes
• abundant nuclear dusts

Treatment is symptomatic.
Resolve spontaneously 1-3 months.
One patient died of myocardial disease.